Commentary: Role of vitamin D in disease through the lens of Mendelian randomization-Evidence from Mendelian randomization challenges the benefits of vitamin D supplementation for disease prevention.

Published on Oct 1, 2019in International Journal of Epidemiology7.339
· DOI :10.1093/ije/dyz183
Despoina Manousaki4
Estimated H-index: 4
(McGill University),
J. Brent Richards45
Estimated H-index: 45
  • References (24)
  • Citations (0)
📖 Papers frequently viewed together
2 Citations
1 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Xia Jiang (Harvard University)H-Index: 6
#2Niki L. Dimou (UoI: University of Ioannina)H-Index: 9
Last. Konstantinos K. Tsilidis (UoB: University of Bristol)H-Index: 17
view all 21 authors...
6 CitationsSource
#1Xiangrui Meng (Edin.: University of Edinburgh)H-Index: 5
#2Xue Li (Edin.: University of Edinburgh)H-Index: 8
Last. Evropi Theodoratou (Edin.: University of Edinburgh)H-Index: 40
view all 17 authors...
2 CitationsSource
#1Kirsty BowmanH-Index: 7
#2Lindsay JonesH-Index: 7
Last. David Melzer MfphmH-Index: 67
view all 8 authors...
Objective To estimate effects of vitamin D levels on incident delirium hospital admissions using inherited genetic variants in mendelian randomization models, which minimize confounding and exclude reverse causation. Methods Longitudinal analysis using the UK Biobank, community-based, volunteer cohort (2006–2010) with incident hospital-diagnosed delirium (ICD-10 F05) ascertained during ≤9.9 years of follow-up of hospitalization records (to early 2016). We included volunteers of European descent ...
2 CitationsSource
#1JoAnn E. Manson (Harvard University)H-Index: 235
#2Nancy R. Cook (Harvard University)H-Index: 107
Last. Julie E. Buring (Harvard University)H-Index: 155
view all 16 authors...
Abstract Background It is unclear whether supplementation with vitamin D reduces the risk of cancer or cardiovascular disease, and data from randomized trials are limited. Methods We conducted a nationwide, randomized, placebo-controlled trial, with a two-by-two factorial design, of vitamin D3 (cholecalciferol) at a dose of 2000 IU per day and marine n−3 (also called omega-3) fatty acids at a dose of 1 g per day for the prevention of cancer and cardiovascular disease among men 50 years of age or...
137 CitationsSource
#1Thor Aspelund (University of Iceland)H-Index: 67
#2Martin R. Grübler (University of Bern)H-Index: 15
Last. Gudny EiriksdottirH-Index: 71
view all 33 authors...
The aim of this study was to determine if increased mortality associated with low levels of serum 25-hydroxyvitamin D (25(OH)D) reflects a causal relationship by using a Mendelian randomisation (MR) approach with genetic variants in the vitamin D synthesis pathway. Individual participant data from three European cohorts were harmonized with standardization of 25(OH)D according to the Vitamin D Standardization Program. Most relevant single nucleotide polymorphisms of the genes CYP2R1 (rs12794714,...
9 CitationsSource
#1Xiao-Mei Mai (NTNU: Norwegian University of Science and Technology)H-Index: 11
#2Vibeke Videm (NTNU: Norwegian University of Science and Technology)H-Index: 32
Last. Yi-Qian Sun (NTNU: Norwegian University of Science and Technology)H-Index: 4
view all 6 authors...
Observational studies have shown consistent associations between higher circulating 25-hydroxyvitamin D [25(OH)D] levels and favorable serum lipids. We sought to investigate if such associations were causal. A Mendelian randomization (MR) study was conducted on a population-based cohort comprising 56,435 adults in Norway. A weighted 25(OH)D allele score was generated based on vitamin D-increasing alleles of rs2282679, rs12785878 and rs10741657. Linear regression analyses of serum lipid levels on...
1 CitationsSource
#1Katerina Trajanoska (EUR: Erasmus University Rotterdam)H-Index: 9
#2John A. Morris (McGill University)H-Index: 10
Last. Fernando Rivadeneira (EUR: Erasmus University Rotterdam)H-Index: 117
view all 9 authors...
Objectives To identify the genetic determinants of fracture risk and assess the role of 15 clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide association studies (GWAS) and a two-sample mendelian randomisation approach. Setting 25 cohorts from Europe, United States, east Asia, and Australia with genome wide genotyping and fracture data. Participants A discovery set of 37 857 fracture cases and 227 116 controls; with replication in up to 147 200 fracture case...
35 CitationsSource
#1Xia Jiang (KI: Karolinska Institutet)H-Index: 6
#2Paul F. O'Reilly ('KCL': King's College London)H-Index: 39
Last. Douglas P. Kiel (MIT: Massachusetts Institute of Technology)H-Index: 98
view all 104 authors...
Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7×10-9 at rs8018720 in SEC...
62 CitationsSource
#1Jun Liu (EUR: Erasmus University Rotterdam)H-Index: 9
#2JJan Bert van Klinken (LUMC: Leiden University Medical Center)H-Index: 1
Last. Ayse Demirkan (EUR: Erasmus University Rotterdam)H-Index: 30
view all 11 authors...
Mendelian randomization (MR) provides us the opportunity to investigate the causal paths of metabolites in type 2 diabetes and glucose homeostasis. We developed and tested an MR approach based on genetic risk scoring for plasma metabolite levels, utilizing a pathway-based sensitivity analysis to control for nonspecific effects. We focused on 124 circulating metabolites that correlate with fasting glucose in the Erasmus Rucphen Family (ERF) study (n = 2,564) and tested the possible causal effect ...
10 CitationsSource
#1Mary R. Rooney (UMN: University of Minnesota)H-Index: 5
#2Lisa J Harnack (UMN: University of Minnesota)H-Index: 58
Last. Pamela L. Lutsey (UMN: University of Minnesota)H-Index: 41
view all 6 authors...
27 CitationsSource
Cited By0