Effect of oxidative stress and 3‐hydroxytyrosol on DNA methylation levels of miR‐9 promoters

Osteoarthritis (OA) is the most common form of arthritis with increasing prevalence. Although it is a multifactorial disease, it is accepted that ageing can induce the onset of OA and has been proposed as the main risk factor of this pathology.1 The main reactive oxygen species (ROS) detected in chondrocytes are peroxynitrite (ONOO−) and hydrogen peroxide (H2O2), and when their overproduction is not counter-balanced by an efficient antioxidant...