Evidence for premature aging in a Drosophila model of Werner syndrome

Volume: 127, Pages: 110733 - 110733
Published: Nov 1, 2019
Abstract
Werner syndrome (WS) is an autosomal recessive progeroid disease characterized by patients' early onset of aging, increased risk of cancer and other age-related pathologies. WS is caused by mutations in WRN, a RecQ helicase that has essential roles responding to DNA damage and preventing genomic instability. While human WRN has both an exonuclease and helicase domain, Drosophila WRNexo has high genetic and functional homology to only the...
Paper Details
Title
Evidence for premature aging in a Drosophila model of Werner syndrome
Published Date
Nov 1, 2019
Volume
127
Pages
110733 - 110733
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