P11.09 Pan-RTK inhibition of sLRIG1 mediates AXL downregulation in Glioblastoma
Abstract
INTRODUCTION Aberrant regulation of receptor tyrosine kinase (RTK) activity is characteristic of Glioblastoma (GBM). However, RTK-based targeted therapies have been largely unsuccessful in GBM patients, partially due to the complexity and redundance of RTK signaling. LRIG1 (Leucine-rich Repeats and ImmunoGlobulindomains protein 1) is known as an endogenous inhibitor of epidermal growth factor receptor (EGFR) during health and disease, however...
Paper Details
Title
P11.09 Pan-RTK inhibition of sLRIG1 mediates AXL downregulation in Glioblastoma
Published Date
Aug 1, 2019
Journal
Volume
21
Issue
Supplement_3
Pages
iii44 - iii44
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