Anxiolytic and anticonvulsant activity followed by molecular docking study of ceramides from the Red Sea sponge Negombata sp

The chemical investigation of the Red Sea sponge Negombata sp. led to isolation and structure elucidation of five new ceramides N ((2S,3R,4E,8E)-1,3-dihydroxyhexacosa-4,8-dien-2-yl)pentadecanamide (1), N-((2S,3R,E)-1,3-dihydroxynonadec-4-en-2-yl)stearamide (2), N-[(2S,3R,E)-1,3 dihydroxyhexacos-4-en-2-yl]palmitamide (3), N-((2S,3R)-1,3-dihydroxydodecan-2-yl)tetradecanamide (4), N-[(2S,3S,4R)-1,3,4- trihydroxypentadecan-2-yl] palmitamide (5)....