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Characteristics recurrence pattern of cholangiolocellular carcinoma as intrahepatic bile duct tumor growth following curative resection: a case report.

Published on Dec 1, 2019in Surgical Case Reports
· DOI :10.1186/s40792-019-0698-2
Keishi Hakoda1
Estimated H-index: 1
,
Tomoyuki Abe12
Estimated H-index: 12
+ 8 AuthorsToshio Noriyuki5
Estimated H-index: 5
(Life Sciences Institute)
Abstract
Background Cholangiolocellular carcinoma (CoCC) is a rare primary liver tumor that shows mass-forming growth in most cases. At present, no effective treatment for hepatic recurrence CoCC has been established. We present a case involving a patient with recurrent disease that showed an intraductal growth (IG type) pattern of recurrence. The patient was treated with repeat hepatectomy with bile duct reconstruction.
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References11
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#1Kentaro Shinohara (Nagoya University)H-Index: 2
#2Tomoki Ebata (Nagoya University)H-Index: 36
Last. Masato Nagino (Nagoya University)H-Index: 63
view all 12 authors...
Cholangiolocellular carcinoma (CoCC) is a rare liver tumor arising from the canals of Hering found between the cholangioles and interlobular bile ducts. Although morphologically CoCC mimics intrahepatic cholangiocarcinoma (ICC), CoCC exhibits a unique intermediate biologic behavior between hepatocellular carcinoma (HCC) and ICC. Curative resection is required for prolonged survival in patients with CoCC. However, effective therapy for postoperative hepatic recurrence has not yet been standardize...
2 CitationsSource
#1Anfeng Si ('SMMU': Second Military Medical University)H-Index: 6
#2Jun Li ('SMMU': Second Military Medical University)H-Index: 14
Last. Feng Shen ('SMMU': Second Military Medical University)H-Index: 32
view all 9 authors...
Background Tumor recurrence after liver resection for intrahepatic cholangiocarcinoma is common. The effective treatment for recurrent intrahepatic cholangiocarcinoma remains to be established. This study evaluated the short- and long-term prognoses of patients after repeat hepatic resection for recurrent intrahepatic cholangiocarcinoma. Methods Data for 72 patients who underwent R0 repeat hepatic resection for recurrent intrahepatic cholangiocarcinoma at the Eastern Hepatobiliary Surgery Hospit...
9 CitationsSource
The patient was a 59-year-old female. A liver tumor measuring 10 cm was found in the right hepatic lobe by medical examination of August, 2008 and she underwent extended right hepatectomy in September. Microscopically, the tumor was composed of small cuboidal cells possessing oval nuclei and resembling cholangiole. These formed small tubular structures with fibrous stroma. From a result of histopathological features, a diagnosis of a cholangiolocellular carcinoma was made. She received postopera...
3 Citations
#1Shun-ichi AriizumiH-Index: 15
#2Yoshihito KoteraH-Index: 13
Last. Masakazu YamamotoH-Index: 151
view all 7 authors...
Background Cholangiolocellular carcinoma (CoCC) has distinct pathological characteristics, and CoCC is considered to originate from hepatic progenitor or stem cells. However, the surgical outcome of CoCC has not been clarified in detail.
30 CitationsSource
#1Mina Komuta (Katholieke Universiteit Leuven)H-Index: 27
#2Olivier Govaere (Katholieke Universiteit Leuven)H-Index: 21
Last. Tania Roskams (Katholieke Universiteit Leuven)H-Index: 79
view all 13 authors...
Cholangiocellular carcinoma (CC) originates from topographically heterogeneous cholangiocytes. The cylindrical mucin-producing cholangiocytes are located in large bile ducts and the cuboidal non–mucin-producing cholangiocytes are located in ductules containing bipotential hepatic progenitor cells (HPCs). We investigated the clinicopathological and molecular features of 85 resected CCs (14 hilar CCs [so-called Klatskin tumor], 71 intrahepatic CCs [ICCs] including 20 cholangiolocellular carcinomas...
146 CitationsSource
INTRODUCTION Invasion of the portal and hepatic veins by hepatocellular carcinoma (HCC) is common, but macroscopic bile duct invasion is rare. Once a tumor thrombus completely obstructs the main bile duct, it causes obstructive jaundice. This type of HCC, known as icteric-type HCC (IHCC), has a poor prognosis.
10 CitationsSource
#1Mina Komuta (Katholieke Universiteit Leuven)H-Index: 27
#2Bart Spee (Katholieke Universiteit Leuven)H-Index: 21
Last. Tania Roskams (Katholieke Universiteit Leuven)H-Index: 79
view all 13 authors...
Cholangiolocellular carcinoma (CLC), a subtype of cholangiocellular carcinoma (CC), is thought to originate from the ductules/canals of Hering, where hepatic progenitor cells (HPCs) are located. We investigated the clinicopathological features of 30 CLCs and their relationship to HPCs. We evaluated the expression of hepatocytic markers (hepatocyte paraffin-1, canalicular polyclonal carcinoembryonic antigen, and CD10), biliary/HPC markers (keratin [K]7, K19, and neural cell adhesion molecule), th...
243 CitationsSource
#1Masami MinagawaH-Index: 18
#2MasatoshiMakuuchiH-Index: 103
Last. Norihiko KokudoH-Index: 67
view all 4 authors...
Objective: The purpose of this study was to evaluate prognostic factors in patients with recurrence after curative resection of hepatocellular carcinoma (HCC) and to identify selection criteria for repeat resection.
298 CitationsSource
We aimed to assess the patterns of recurrence after surgery for intrahepatic cholangiocarcinoma (ICC) and the outcomes of treatment in patients with recurrence. From 1981 to 1999, 123 patients with ICC underwent hepatectomy. The 3-year and 5-year survival rates were significantly higher in patients after curative resection (n = 56; 53%, 50%) than in patients after noncurative resection (n = 67; 7%, 2%; P < 0.0001). In 54 patients followed-up after curative resection, the rate of recurrence after...
76 CitationsSource
#1Koji Shiota (Kurume University)H-Index: 5
#2Jun TaguchiH-Index: 9
Last. MasamichiKojiroH-Index: 67
view all 5 authors...
We clinicopathologically studied 6 resected cases of cholangiolocarcinoma (CLC) including 2 referred cases from other hospitals. The frequency of CLC was 0.56% of the 708 consecutively resected cases of primary liver cancer and the mean age of CLC cases was 66 years. Three of the 6 cases (50%) were hepatitis C virus antibody (HCVab) positive, one (17%) was hepatitis B virus surface antigen (HBsAg) positive, and 2 (33%) were negative to both HCVAb and HBsAg. Serum levels of α-fetoprotein were sli...
70 CitationsSource
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