Impaired turnover of hyperfused mitochondria in severe axonal neuropathy due to a novel DRP1 mutation
Abstract
Mitochondria undergo continuous cycles of fusion and fission in response to physiopathological stimuli. The key player in mitochondrial fission is dynamin-related protein 1 (DRP1), a cytosolic protein encoded by dynamin 1-like (DNM1L) gene, which relocalizes to the outer mitochondrial membrane, where it assembles, oligomerizes and drives mitochondrial division upon guanosine-5′-triphosphate (GTP) hydrolysis. Few DRP1 mutations have been...
Paper Details
Title
Impaired turnover of hyperfused mitochondria in severe axonal neuropathy due to a novel DRP1 mutation
Published Date
Sep 7, 2019
Journal
Volume
29
Issue
2
Pages
177 - 188
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History