Abstract P110: Classical Dendritic Cells Mediate Hypertension by Promoting Oxidative Stress and Renal Fluid Retention

Dendritic cells (DCs) promote hypertension via the activation of T cells, but the specific DC subtypes that mediate hypertension require elucidation. We previously found that Fms-like tyrosine kinase 3 ligand-deficient (FLT3L -/- ) mice that lack classical CD11c hi MHCII hi DCs have blunted renal accumulation of effector T cells vs wild-type (WT) mice during chronic angiotensin (Ang) II infusion (500ng/kg/min). In the current studies, we tested...