CRISPR DNA base editors with reduced RNA off-target and self-editing activities
Abstract
Cytosine or adenine base editors (CBEs or ABEs) can introduce specific DNA C-to-T or A-to-G alterations1–4. However, we recently demonstrated that they can also induce transcriptome-wide guide-RNA-independent editing of RNA bases5, and created selective curbing of unwanted RNA editing (SECURE)-BE3 variants that have reduced unwanted RNA-editing activity5. Here we describe structure-guided engineering of SECURE-ABE variants with reduced...
Paper Details
Title
CRISPR DNA base editors with reduced RNA off-target and self-editing activities
Published Date
Sep 1, 2019
Journal
Volume
37
Issue
9
Pages
1041 - 1048
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Notes
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