NPA: an R package for computing network perturbation amplitudes using gene expression data and two-layer networks
Abstract
High-throughput gene expression technologies provide complex datasets reflecting mechanisms perturbed in an experiment, typically in a treatment versus control design. Analysis of these information-rich data can be guided based on a priori knowledge, such as networks of related proteins or genes. Assessing the response of a specific mechanism and investigating its biological basis is extremely important in systems toxicology; as compounds or...
Paper Details
Title
NPA: an R package for computing network perturbation amplitudes using gene expression data and two-layer networks
Published Date
Sep 3, 2019
Journal
Volume
20
Issue
1
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