Associations of autozygosity with a broad range of human phenotypes
Abstract
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p...
Paper Details
Title
Associations of autozygosity with a broad range of human phenotypes
Published Date
Oct 31, 2019
Journal
Volume
10
Issue
1
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