Iron chelation by deferasirox confers protection against concanavalin A-induced liver fibrosis: A mechanistic approach
Abstract
Hepatic iron overload is one of the causative factors for chronic liver injury and fibrosis. The present study aimed to investigate the potential antifibrotic effect of the iron chelator; deferasirox (DFX) in experimentally-induced liver fibrosis in rats. Male Sprague-Dawley rats were administered concanavalin A (Con A) and/or DFX for 6 consecutive weeks. Con A injection induced significant hepatotoxicity as was evident by the elevated...
Paper Details
Title
Iron chelation by deferasirox confers protection against concanavalin A-induced liver fibrosis: A mechanistic approach
Published Date
Nov 1, 2019
Volume
382
Pages
114748 - 114748
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