Mechanisms and Implications of Metabolic Heterogeneity in Cancer
Abstract
Tumors display reprogrammed metabolic activities that promote cancer progression. We currently possess a limited understanding of the processes governing tumor metabolism in vivo and of the most efficient approaches to identify metabolic vulnerabilities susceptible to therapeutic targeting. While much of the literature focuses on stereotyped, cell-autonomous pathways like glycolysis, recent work emphasizes heterogeneity and flexibility of...
Paper Details
Title
Mechanisms and Implications of Metabolic Heterogeneity in Cancer
Published Date
Sep 1, 2019
Journal
Volume
30
Issue
3
Pages
434 - 446
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