Extreme inbreeding in a European ancestry sample from the contemporary UK population
Abstract
In most human societies, there are taboos and laws banning mating between first- and second-degree relatives, but actual prevalence and effects on health and fitness are poorly quantified. Here, we leverage a large observational study of ~450,000 participants of European ancestry from the UK Biobank (UKB) to quantify extreme inbreeding (EI) and its consequences. We use genotyped SNPs to detect large runs of homozygosity (ROH) and call EI when...
Paper Details
Title
Extreme inbreeding in a European ancestry sample from the contemporary UK population
Published Date
Sep 3, 2019
Journal
Volume
10
Issue
1
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