Upregulation of intratumoral HLA class I and peritumoral Mx1 in ulcerated melanomas
Abstract
Before the era of immune checkpoint blockade, a meta-analysis encompassing fifteen trials reported that adjuvant IFN-α significantly reduces the risk of relapse and improves survival of ulcerated melanoma (UM) with no benefit for higher doses compared to lower doses. IFNa2b affects many cell intrinsic features of tumor cells and modulates the host innate and cognate immune responses. To better understand the biological traits associated with...
Paper Details
Title
Upregulation of intratumoral HLA class I and peritumoral Mx1 in ulcerated melanomas
Published Date
Sep 6, 2019
Journal
Volume
8
Issue
11
Pages
e1660121 - e1660121
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Notes
History