Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors
Volume: 29, Issue: 20, Pages: 126675 - 126675
Published: Oct 1, 2019
Abstract
The connection between Netherton syndrome and overactivation of epidermal/dermal proteases, particularly Kallikrein 5 (KLK5) has been well established and it is expected that a KLK5 inhibitor would improve the dermal barrier and also reduce the pain and itch that afflict Netherton syndrome patients. One of the challenges of covalent protease inhibitors has been achieving selectivity over closely related targets. In this paper we describe the use...
Paper Details
Title
Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors
Published Date
Oct 1, 2019
Volume
29
Issue
20
Pages
126675 - 126675
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