Checkpoint Inhibition and Infectious Diseases: A Good Thing?
Abstract
The mammalian immune system has evolved the capacity to detect and destroy tumor cells. Tumors utilize multiple strategies to evade host immune surveillance, including the induction of the checkpoint molecules cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) to suppress antitumor immunity. Pharmacologic blockade of these molecules with checkpoint inhibitors (CPIs) restores T cell function and...
Paper Details
Title
Checkpoint Inhibition and Infectious Diseases: A Good Thing?
Published Date
Dec 1, 2019
Journal
Volume
25
Issue
12
Pages
1080 - 1093
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Notes
History