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Neuregulin 4: A “Hotline” Between Brown Fat and Liver

Published on Oct 1, 2019in Obesity3.969
· DOI :10.1002/oby.22595
Matthias Blüher79
Estimated H-index: 79
(Leipzig University)
Sources
Abstract
The discovery that functional brown adipose tissue (BAT) in adult humans is inversely related to body fat mass and may reflect metabolic health has stimulated adipose tissue research to explore activation of BAT as a potential target for antiobesity treatments. In addition to the capacity of BAT to increase energy expenditure and glucose and lipid uptake, BAT secretes factors that may contribute to the regulation of whole‐body metabolism. Among signals released from BAT, neuregulin 4 (NRG4) has been recently identified as an endocrine factor that may link the activation of BAT to protection against diet‐induced obesity, insulin resistance, and hepatic steatosis. NRG4 was shown to directly reduce lipogenesis in hepatocytes, and it could indirectly activate BAT via sympathetic neurons or via inducing brown adipocyte–like signatures in white adipocytes in a paracrine manner. However, the potential relevance of NRG4 as a diagnostic tool or target for the treatment of obesity‐related diseases remains to be explored.
  • References (12)
  • Citations (1)
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References12
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#1Joan Villarroya (University of Barcelona)H-Index: 17
#2Rubén Cereijo (University of Barcelona)H-Index: 11
Last. Francesc Villarroya (University of Barcelona)H-Index: 40
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Background. The secretory properties of brown adipose tissue are thought to contribute to the association between active brown fat and a healthy metabolic status. Although a few brown adipokines have been identified, a comprehensive knowledge of the brown adipose tissue secretome is lacking. Methods. Here, to examine the effects of thermogenic activation of brown adipocytes on protein secretion, we used isobaric tags for relative and absolute quantification (iTRAQ) analysis to determine how the ...
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#1Vanessa Pellegrinelli (University of Cambridge)H-Index: 7
#2Vivian Peirce (University of Cambridge)H-Index: 5
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Activation of brown adipose tissue-mediated thermogenesis is a strategy for tackling obesity and promoting metabolic health. BMP8b is secreted by brown/beige adipocytes and enhances energy dissipation. Here we show that adipocyte-secreted BMP8b contributes to adrenergic-induced remodeling of the neuro-vascular network in adipose tissue (AT). Overexpression of bmp8b in AT enhances browning of the subcutaneous depot and maximal thermogenic capacity. Moreover, BMP8b-induced browning, increased symp...
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#2Kong Y. Chen (NIH: National Institutes of Health)H-Index: 43
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#1Alexander Pfeifer (University of Bonn)H-Index: 53
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#2Myrsini Kaforou (Imperial College London)H-Index: 9
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#1Michael P. Czech (UMMS: University of Massachusetts Medical School)H-Index: 91
Abstract Background The diminished glucose lowering effect of insulin in obesity, denoted “insulin resistance”, is associated with glucose intolerance, type 2 diabetes and other serious maladies. Many thousands of publications on the topic have suggested dozens of hypotheses on the molecular and cellular disruptions that contribute to the syndrome. Yet there is still deep uncertainty on the mechanisms of its initiation and long term maintenance. Scope of review To simplify analysis of insulin re...
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