Fate‐mapping analysis using Rorb‐IRES‐Cre reveals apical‐to‐basal gradient of Rorb expression in mouse cochlea

Background Conditional loss‐of‐function studies are widely conducted using the Cre/Loxp system because this helps circumvent embryonic or neonatal lethality problems. However, Cre strains specific to the inner ear are lacking, and thus lethality frequently occurs even in conditional knockout studies. Results Here, we report a Rorb‐IRES‐Cre knockin mouse strain in which the Cre recapitulates the expression pattern of endogenous Rorb (RAR‐related...