Match!

Cannabis and Cannabinoid Biology in Stroke

Published on Aug 1, 2019in Stroke6.058
· DOI :10.1161/STROKEAHA.118.023587
Sang-Ho Choi11
Estimated H-index: 11
,
Sang-Ho Choi1
Estimated H-index: 1
(University of Pittsburgh)
+ 0 AuthorsAfonso C. Silva1
Estimated H-index: 1
(University of Pittsburgh)
Abstract
  • References (63)
  • Citations (3)
📖 Papers frequently viewed together
2012
1 Author (Alison Ribeiro)
2018
1 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References63
Newest
#1Justin S. CisarH-Index: 10
#2Olivia D. WeberH-Index: 2
Last. Cheryl A. GriceH-Index: 10
view all 11 authors...
The serine hydrolase monoacylglycerol lipase (MGLL) converts the endogenous cannabinoid receptor agonist 2-arachidonoylglycerol (2-AG) and other monoacylglycerols into fatty acids and glycerol. Genetic or pharmacological inactivation of MGLL leads to elevation in 2-AG in the central nervous system and corresponding reductions in arachidonic acid and eicosanoids, producing antinociceptive, anxiolytic, and antineuroinflammatory effects without inducing the full spectrum of psychoactive effects of ...
10 CitationsSource
4 CitationsSource
BACKGROUND: Cannabis for medicinal and/or recreational purposes has been decriminalized in 28 states as of the 2016 election. In the remaining states, cannabis remains the most commonly used illicit drug. Cardiovascular effects of cannabis use are not well established due to a limited number of studies. We therefore utilized a large national database to examine the prevalence of cardiovascular risk factors and events amongst patients with cannabis use. METHODS: Patients aged 18-55 years with can...
4 CitationsSource
#1Marc P. Baggelaar (LEI: Leiden University)H-Index: 11
#2Mauro Maccarrone (Sapienza University of Rome)H-Index: 68
Last. Mario van der Stelt (LEI: Leiden University)H-Index: 25
view all 3 authors...
Abstract 2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the cannabinoid CB 1 receptor. It is involved in a wide array of (patho)physiological functions, such as emotion, cognition, energy balance, pain sensation and neuroinflammation. In this review, we describe the biosynthetic and metabolic pathways of 2-AG and how chemical and genetic perturbation of these pathways ...
15 CitationsSource
#1Justin R. Piro (Pfizer)H-Index: 4
#2Georgette Suidan (Pfizer)H-Index: 2
Last. Tarek A. Samad (Pfizer)H-Index: 11
view all 11 authors...
Background Acute neurological insults caused by infection, systemic inflammation, ischemia, or traumatic injury are often associated with breakdown of the blood-brain barrier (BBB) followed by infiltration of peripheral immune cells, cytotoxic proteins, and water. BBB breakdown and extravasation of these peripheral components into the brain parenchyma result in inflammation, oxidative stress, edema, excitotoxicity, and neurodegeneration. These downstream consequences of BBB dysfunction can drive...
3 CitationsSource
#1Emelia J. BenjaminH-Index: 154
#2Salim S. ViraniH-Index: 37
Last. Paul MuntnerH-Index: 92
view all 51 authors...
Each chapter listed in the Table of Contents (see next page) is a hyperlink to that chapter. The reader clicks the chapter name to access that chapter. Each chapter listed here is a hyperlink. Click on the chapter name to be taken to that chapter. Each year, the American Heart Association (AHA), in conjunction with the Centers for Disease Control and Prevention, the National Institutes of Health, and other government agencies, brings together in a single document the most up-to-date statistics r...
1,241 CitationsSource
#2Eric D. Marsh (Children's Hospital of Philadelphia)H-Index: 25
#3J. French (NYU: New York University)H-Index: 3
Last. Angus A. WilfongH-Index: 19
view all 44 authors...
Summary Background Patients with Lennox-Gastaut syndrome, a rare, severe form of epileptic encephalopathy, are frequently treatment resistant to available medications. No controlled studies have investigated the use of cannabidiol for patients with seizures associated with Lennox-Gastaut syndrome. We therefore assessed the efficacy and safety of cannabidiol as an add-on anticonvulsant therapy in this population of patients. Methods In this randomised, double-blind, placebo-controlled trial done ...
119 CitationsSource
#1Sang-Ho ChoiH-Index: 11
#2Allison L. AraiH-Index: 1
Last. Afonso C. SilvaH-Index: 35
view all 7 authors...
Background and Purpose— MAGL (monoacylglycerol lipase) is an enzyme that hydrolyzes the endocannabinoid 2-arachidonoylglycerol and regulates the production of arachidonic acid and prostaglandins—substances that mediate tissue inflammatory response. Here, we have studied the effects of the selective MAGL inhibitors JZL184 and MJN110 and their underlying molecular mechanisms on 3 different experimental models of focal cerebral ischemia. Methods— SHR (spontaneously hypertensive rats) and normotensi...
4 CitationsSource
#1Noor Azuin Suliman (UPM: Universiti Putra Malaysia)H-Index: 3
#2Che Norma Mat Taib (UPM: Universiti Putra Malaysia)H-Index: 5
Last. Rusliza Basir (UPM: Universiti Putra Malaysia)H-Index: 11
view all 4 authors...
Neurogenesis is influenced by various external factors such as enriched environments. Some researchers had postulated that neurogenesis has contributed to the hippocampal learning and memory. This project was designed to observe the effect of Delta-9-tetrahydrocannabinol (∆9-THC) in cognitive performance that influenced by the neurogenesis. Different doses of ∆9-THC were used for observing the neurogenesis mechanism occurs in the hippocampus of rats. The brains were stained with antibodies, name...
11 CitationsSource
#1Carlotta Granchi (UniPi: University of Pisa)H-Index: 19
#2Isabella CaligiuriH-Index: 13
Last. Tiziano Tuccinardi (College of Science and Technology)H-Index: 29
view all 5 authors...
ABSTRACTIntroduction: Monoacylglycerol lipase is a serine hydrolase that plays a major role in the degradation of the endocannabinoid 2-arachidonoylglycerol. Because of this key role, selective inactivation of MAGL represents an interesting approach to obtain desirable effects in several diseases. Furthermore, MAGL is upregulated in cancer cells and primary tumors and its inhibition in aggressive breast, ovarian, and melanoma cancer cells impairs cell migration, invasiveness, and tumorigenicity....
15 CitationsSource
Cited By3
Newest
#1Kevin McKernanH-Index: 19
#2Liam T. KaneH-Index: 1
Last. Yvonne HelbertH-Index: 4
view all 3 authors...
In January of 2020, COVID-19 became a worldwide pandemic. As many industries shutdown to comply with social distancing measures, the cannabis industry was deemed an essential business in most US jurisdictions. Cannabis is manually farmed, trimmed and packaged and as a result can be a potential inhaled SARs-CoV-2 fomite. Many of the comorbidities described in COVID-19 are also qualifying conditions for medical cannabis access. Bat Guano has been identified as a rich source for novel coronavirus d...
Source
Cannabis-inspired medical products are garnering increasing attention from the scientific community, general public, and health policy makers. A plethora of scientific literature demonstrates intricate engagement of the endocannabinoid system with human immunology, psychology, developmental processes, neuronal plasticity, signal transduction, and metabolic regulation. Despite the therapeutic potential, the adverse psychoactive effects and historical stigma, cannabinoids have limited widespread c...
2 CitationsSource
#1Tarang Parekh (GMU: George Mason University)H-Index: 1
#2Sahithi PemmasaniH-Index: 1
Last. Rupak DesaiH-Index: 5
view all 3 authors...
Background and Purpose of marijuana/cannabis in the United States, cerebrovascular effects of marijuana use remain largely unknown, especially among young adults. We aimed to examine the association between marijuana use (18-44 years) among young adults and stroke events. Methods- The study analyzed pooled data from the Behavioral Risk Factor Surveillance System (2016-2017)-a nationally representative cross-sectional survey collected by the Centers for Disease Control and Prevention. Weighted lo...
Source
#1Tarang ParekhH-Index: 1
#2Sahithi PemmasaniH-Index: 1
Last. Rupak DesaiH-Index: 5
view all 3 authors...
Background and Purpose— Amidst legalization of therapeutic and recreational use of marijuana/cannabis in the United States, cerebrovascular effects of marijuana use remain largely unknown, especial...
3 CitationsSource