Enhanced mTOR complex 1 signaling attenuates diabetic cardiac injury in OVE26 mice
Abstract
The protein kinase mechanistic target of rapamycin (mTOR) performs diverse cellular functions through 2 distinct multiprotein complexes, mTOR complex (mTORC)1 and 2. Numerous studies using rapamycin, an mTORC1 inhibitor, have implicated a role for mTORC1 in several types of heart disease. People with diabetes are more susceptible to heart failure. mTORC1 activity is increased in the diabetic heart, but its functional significance remains...
Paper Details
Title
Enhanced mTOR complex 1 signaling attenuates diabetic cardiac injury in OVE26 mice
Published Date
Aug 30, 2019
Journal
Volume
33
Issue
11
Pages
12800 - 12811
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