The Ovulatory Signal Precipitates LRH-1 Transcriptional Switching Mediated by Differential Chromatin Accessibility
Abstract
•The LH signal initiates extensive chromatin remodeling in the ovarian follicle•LRH-1-specific DNA sequence motifs are found in open chromatin domains•Dynamic LRH-1 cistrome reprogramming controls granulosa cells differentiation•LRH-1 directly regulates early events leading to ovulation In the ovary, follicular growth and maturation are complicated processes that involve a series of morphological and physiological changes in oocytes and somatic...
Paper Details
Title
The Ovulatory Signal Precipitates LRH-1 Transcriptional Switching Mediated by Differential Chromatin Accessibility
Published Date
Aug 1, 2019
Journal
Volume
28
Issue
9
Pages
2443 - 2454.e4
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