Genome sequencing for early-onset dementia: high diagnostic yield and frequent observation of multiple contributory alleles

Pages: 748046
Published: Aug 28, 2019
Abstract
null We assessed the utility of genome sequencing for early-onset dementia. Participants were selected from a memory disorders clinic. Genome sequencing was performed along with C9orf72 repeat expansion testing. All returned sequencing results were Sanger validated clinically. Prior clinical diagnoses included Alzheimer’s disease, frontotemporal dementia, and unspecified dementia. The mean age-of-onset was 54 (41–76). 50% of patients had a...
Paper Details
Title
Genome sequencing for early-onset dementia: high diagnostic yield and frequent observation of multiple contributory alleles
Published Date
Aug 28, 2019
Journal
Pages
748046
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