TNF-α Suppresses Autophagic Flux in Acinar Cells in IgG4-Related Sialadenitis
Abstract
IgG4-related sialadenitis (IgG4-RS) is a newly recognized immune-mediated systemic fibroinflammatory disease that affects salivary glands and leads to hyposalivation. Tumor necrosis factor-α (TNF-α) is a critical proinflammatory cytokine involved in several salivary gland disorders, but its role and mechanism regarding acinar cell injury in IgG4-RS are unknown. Here, we found that TNF-α level was significantly increased in serum and...
Paper Details
Title
TNF-α Suppresses Autophagic Flux in Acinar Cells in IgG4-Related Sialadenitis
Published Date
Aug 28, 2019
Journal
Volume
98
Issue
12
Pages
1386 - 1396
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