The Influence of Molecular Reach and Diffusivity on the Efficacy of Membrane-Confined Reactions
Abstract
Signaling by surface receptors often relies on tethered reactions whereby an enzyme bound to the cytoplasmic tail of a receptor catalyzes reactions on substrates within reach. The overall length and stiffness of the receptor tail, the enzyme, and the substrate determine a biophysical parameter termed the molecular reach of the reaction. This parameter determines the probability that the receptor-tethered enzyme will contact the substrate in the...
Paper Details
Title
The Influence of Molecular Reach and Diffusivity on the Efficacy of Membrane-Confined Reactions
Published Date
Oct 1, 2019
Journal
Volume
117
Issue
7
Pages
1189 - 1201
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