Superoxide Dismutase 3 Inhibits LL-37/KLK-5–Mediated Skin Inflammation through Modulation of EGFR and Associated Inflammatory Cascades

The expressions of LL-37 and KLK-5 were found to be altered in various dermatoses, including atopic dermatitis, psoriasis, and rosacea. However, the downstream inflammatory effect of LL-37 and KLK-5 is not as well studied. In addition, there is little high-quality evidence for the treatment of LL-37– and KLK-5–mediated inflammation. In this study, we investigated the effect of superoxide dismutase 3 (SOD3) on LL-37– or KLK-5–induced skin...