Original paper
Progranulin deficiency confers resistance to autoimmune encephalomyelitis in mice
Volume: 17, Issue: 10, Pages: 1077 - 1091
Published: Aug 29, 2019
Abstract
Progranulin is a secreted neurotrophin that assists in the autophagolysosomal pathways that contribute to MHC-mediated antigen processing, pathogen removal, and autoimmunity. We showed that patients with multiple sclerosis (MS) have high levels of circulating progranulin and that its depletion in a mouse model by a monoclonal antibody aggravates MS-like experimental autoimmune encephalomyelitis (EAE). However, unexpectedly, progranulin-deficient...
Paper Details
Title
Progranulin deficiency confers resistance to autoimmune encephalomyelitis in mice
Published Date
Aug 29, 2019
Volume
17
Issue
10
Pages
1077 - 1091
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Notes
History