Impacts of GFP-FoxP3+regulatory T cells on lupus hallmarks differ by genetic background and type of GFP knock-in
Abstract
FoxP3 reporter mice expressing green fluorescence protein (GFP) have been used as a very convenient tool to investigate the impact of regulatory T (Treg) cells on pathogenesis in autoimmune diseases. Here, we found that GFP-FoxP3+ knock-in (KI) mice showed alterations in the production of anti-nuclear autoantibodies (ANAs) and nephritis with different extent, depending on the presence or absence of lupus susceptibility gene locus 1 (Sle1) and KI...
Paper Details
Title
Impacts of GFP-FoxP3+regulatory T cells on lupus hallmarks differ by genetic background and type of GFP knock-in
Published Date
Aug 18, 2019
Journal
Volume
52
Issue
5-6
Pages
199 - 207
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