Circulating microRNAs as Potential Minimal Residual Disease Biomarkers in Pediatric Acute Lymphoblastic Leukemia

The most common pediatric malignancy is the acute lymphoblastic leukemia (ALL). It takes almost one third of all childhood malignancies. Monitoring of minimal residual disease (MRD) is elementary in clinical practice for further improve survival. Extracellular vesicles such as exosomes containing microRNAs are biomarker candidates in several malignancies as well as in other conditions. In pediatric leukemia the function of extracellular vesicles...