Pharmacology of mitochondrial permeability transition pore inhibitors
Abstract
It is now firmly established that an important event in the formation of reperfusion injury of the heart is the opening of mitochondrial permeability transition pores (mPTPs), which changes the permeability of the mitochondria. mPTP opening results in the death of cardiomyocytes through activation of apoptosis and necroptosis. Experimental studies have shown that pharmacological inhibition of mPTP opening promotes the reduction in the infarct...
Paper Details
Title
Pharmacology of mitochondrial permeability transition pore inhibitors
Published Date
Aug 24, 2019
Journal
Volume
80
Issue
8
Pages
1013 - 1030
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