Germline mutation in DNA ‐repair genes is associated with poor survival in BRCA 1/2‐ negative breast cancer patients

BRCA 1/2 genes are the most frequently germline mutated DNA ‐repair genes, and the survival of BRCA 1/2 carriers has been extensively explored in breast cancer. However, the prevalence of germline mutations in non‐ BRCA 1/2 DNA ‐repair genes and the survival of carriers are largely unknown in a large cohort of unselected breast cancer patients. Germline mutations in 16 DNA ‐repair genes were determined using a multigene panel in 7657 BRCA 1/2...