Age-related clonal haemopoiesis is associated with increased epigenetic age

Age-related clonal haemopoiesis (ARCH) in healthy individuals was initially observed through an increased skewing in X-chromosome inactivation [1Busque L. Mio R. Mattioli J. Brais E. Blais N. Lalonde Y. Maragh M. Gilliland D.G. Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age.Blood. 1996; 88: 59-65Crossref PubMed Google Scholar]. More recently, several groups reported that ARCH is driven by somatic mutations...