Oral Selinexor–Dexamethasone for Triple-Class Refractory Multiple Myeloma

Selinexor, a selective inhibitor of nuclear export compound that blocks exportin 1 (XPO1) and forces nuclear accumulation and activation of tumor suppressor proteins, inhibits nuclear factor κB, and reduces oncoprotein messenger RNA translation, is a potential novel treatment for myeloma that is refractory to current therapeutic options.We administered oral selinexor (80 mg) plus dexamethasone (20 mg) twice weekly to patients with myeloma who...