Caspase-11-dependent IL-1α release boosts Th17 immunity against Paracoccidioides brasiliensis
Abstract
The granulomatous lesion resulting from infection with the fungus Paracoccidioides brasiliensis is characterized by a compact aggregate of mature cells, surrounded by a fibroblast- and collagen-rich content. Granuloma formation requires signaling elicited by inflammatory molecules such as members of the interleukin-1 family. Two members of this family have been thoroughly studied, namely IL-1α and IL-1β. In this study, we addressed the...
Paper Details
Title
Caspase-11-dependent IL-1α release boosts Th17 immunity against Paracoccidioides brasiliensis
Published Date
Aug 19, 2019
Journal
Volume
15
Issue
8
Pages
e1007990 - e1007990
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