Increasing protein stability by association with zwitterionic amphiphile cocamidopropyl betaine
Abstract
Stability of therapeutic proteins is one of the most important obstacles in their development. We studied the effects of the zwitterionic amphiphile cocamidopropyl betaine (CAPB) on protein stability against elevated temperatures and shear. Bovine serum albumin (BSA) was selected as a model protein to study the interaction with CAPB. Techniques such as gel electrophoresis, fluorimetry, and surface tensiometry were utilized to study protein...
Paper Details
Title
Increasing protein stability by association with zwitterionic amphiphile cocamidopropyl betaine
Published Date
Dec 1, 2019
Journal
Volume
295
Pages
111631 - 111631
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