Enteroids expressing a disease-associated mutant of EpCAM are a model for congenital tufting enteropathy
Volume: 317, Issue: 5, Pages: G580 - G591
Published: Nov 1, 2019
Abstract
Congenital tufting enteropathy (CTE) is an autosomal recessive disease characterized by severe intestinal failure in infancy and mutations in the epithelial cell adhesion molecule ( EPCAM) gene. Previous studies of CTE in mice expressing mutant EpCAM show neonatal lethality. Hence, to study the cellular, molecular, and physiological alterations that result from EpCAM mutation, a tamoxifen-inducible mutant EpCAM enteroid model has been generated....
Paper Details
Title
Enteroids expressing a disease-associated mutant of EpCAM are a model for congenital tufting enteropathy
Published Date
Nov 1, 2019
Volume
317
Issue
5
Pages
G580 - G591
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