Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview

Although flavonoid compounds have various pharmacological applications, they generally exhibit low oral bioavailability due to their poor aqueous solubility. To address this problem, numerous promising strategies, such as the use of an absorption enhancer, structural transformation (e.g., prodrugs, glycosylation), and pharmaceutical technologies (e.g., carrier complexes, nanotechnology, cocrystals), have been developed and applied to deliver...