NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis
Abstract
Macrophage activation is implicated in the development of pulmonary fibrosis by generation of profibrotic molecules. Although NADPH oxidase 4 (NOX4) is known to contribute to pulmonary fibrosis, its effects on macrophage activation and mitochondrial redox signaling are unclear. Here, we show that NOX4 is crucial for lung macrophage profibrotic polarization and fibrotic repair after asbestos exposure. NOX4 was elevated in lung macrophages from...
Paper Details
Title
NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis
Published Date
Aug 22, 2019
Journal
Volume
4
Issue
16
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