A CsrA-Binding, trans -Acting sRNA of Coxiella burnetii Is Necessary for Optimal Intracellular Growth and Vacuole Formation during Early Infection of Host Cells

Volume: 201, Issue: 22
Published: Nov 15, 2019
Abstract
Regulation of metabolism and virulence in C. burnetii is not well understood. Here, we show that C. burnetii small RNA 12 (CbsR12) is highly transcribed in the metabolically active large-cell variant compared to the nonreplicative small-cell variant. We show that CbsR12 directly regulates several genes involved in metabolism, along with a type IV effector gene, in trans . In addition, we demonstrate that CbsR12 binds to CsrA-2 in vitro and...
Paper Details
Title
A CsrA-Binding, trans -Acting sRNA of Coxiella burnetii Is Necessary for Optimal Intracellular Growth and Vacuole Formation during Early Infection of Host Cells
Published Date
Nov 15, 2019
Volume
201
Issue
22
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