cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice

Volume: 39, Issue: 12, Pages: 2379 - 2391
Published: Aug 18, 2019
Abstract
Recent works highlight the therapeutic potential of targeting cyclic guanosine monophosphate (cGMP)-dependent pathways in the context of brain ischemia/reperfusion injury (IRI). Although cGMP-dependent protein kinase I (cGKI) has emerged as a key mediator of the protective effects of nitric oxide (NO) and cGMP, the mechanisms by which cGKI attenuates IRI remain poorly understood. We used a novel, conditional cGKI knockout mouse model to study...
Paper Details
Title
cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice
Published Date
Aug 18, 2019
Volume
39
Issue
12
Pages
2379 - 2391
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