Thrombin: Coagulation's master regulator of innate immunity

The survival of all organisms depends on their ability to mount a rapid and effective response to injury, with coordinated activation of innate biological systems that limit bleeding, restrict the spread of infection and tissue damage, and promote healing. The complex network that comprises coagulation and the various components of innate immunity (ie, complement activation, inflammation, leukocyte infiltration/activation) is highly integrated...