Original paper
Differential long‐term regulation of TAS2R14 by structurally distinct agonists
Abstract
Bitter taste receptor-14 (TAS2R14) is a GPCR also expressed on human airway smooth muscle cells, which signals to intracellular [Ca2+], resulting in relaxation of the airway, and is a novel target for bronchodilators. Here, we examine long-term, agonist-promoted down-regulation of TAS2R14 expression because tachyphylaxis would be an undesirable therapeutic characteristic. Five TAS2R structurally distinct full agonists were studied to ascertain...
Paper Details
Title
Differential long‐term regulation of TAS2R14 by structurally distinct agonists
Published Date
Aug 20, 2019
Journal
Volume
33
Issue
11
Pages
12213 - 12225
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Notes
History