Synthesis of Benzo[b]azocin-2-ones by Aryl Amination and Ring-Expansion of α-(Iodophenyl)-β-oxoesters.
Abstract
Transformation of β-oxoesters with PhI(OCOCF3 )2 leads to α-(ortho-iodophenyl)-β-oxoesters. These materials are the starting point for the synthesis of 6-carboxybenzo[b]azocin-2-ones by a sequence of aryl amination and ring transformation. This reaction sequence starts with copper-catalyzed formation of N-alkyl anilines from the iodoarenes and primary amines in the presence of K3 PO4 as stoichiometric base. The intermediate products underwent...
Paper Details
Title
Synthesis of Benzo[b]azocin-2-ones by Aryl Amination and Ring-Expansion of α-(Iodophenyl)-β-oxoesters.
Published Date
Nov 22, 2019
Volume
25
Issue
65
Pages
14912 - 14920
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