Mechanism of Filamentation-Induced Allosteric Activation of the SgrAI Endonuclease

Volume: 27, Issue: 10, Pages: 1497 - 1507.e3
Published: Oct 1, 2019
Abstract
•A 3.5-Å cryo-EM structure of the filamentous form of DNA-bound SgrAI•Conformational changes play a role in catalytic Mg2+ stabilization•New configuration explains enzyme activation in filamentous state•Indirect readout of DNA structure associated with SgrAI filamentation and activity Filament formation by enzymes is increasingly recognized as an important phenomenon with potentially unique regulatory properties and biological roles. SgrAI is an...
Paper Details
Title
Mechanism of Filamentation-Induced Allosteric Activation of the SgrAI Endonuclease
Published Date
Oct 1, 2019
Journal
Volume
27
Issue
10
Pages
1497 - 1507.e3
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.