A transient reporter for editing enrichment (TREE) in human cells

Volume: 47, Issue: 19, Pages: e120 - e120
Published: Aug 20, 2019
Abstract
Current approaches to identify cell populations that have been modified with deaminase base editing technologies are inefficient and rely on downstream sequencing techniques. In this study, we utilized a blue fluorescent protein (BFP) that converts to green fluorescent protein (GFP) upon a C-to-T substitution as an assay to report directly on base editing activity within a cell. Using this assay, we optimize various base editing transfection...
Paper Details
Title
A transient reporter for editing enrichment (TREE) in human cells
Published Date
Aug 20, 2019
Volume
47
Issue
19
Pages
e120 - e120
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