G protein-coupled receptors in acquired epilepsy: Druggability and translatability
Abstract
As the largest family of membrane proteins in the human genome, G protein-coupled receptors (GPCRs) constitute the targets of more than one-third of all modern medicinal drugs. In the central nervous system (CNS), widely distributed GPCRs in neuronal and nonneuronal cells mediate numerous essential physiological functions via regulating neurotransmission at the synapses. Whereas their abnormalities in expression and activity are involved in...
Paper Details
Title
G protein-coupled receptors in acquired epilepsy: Druggability and translatability
Published Date
Dec 1, 2019
Journal
Volume
183
Pages
101682 - 101682
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