The effect of propofol on hypoxia-modulated expression of heat shock proteins: potential mechanism in modulating blood–brain barrier permeability
Volume: 462, Issue: 1-2, Pages: 85 - 96
Published: Aug 24, 2019
Abstract
Heat shock proteins (HSPs) may be induced by hypoxia and alleviate blood–brain barrier (BBB) damage. The neuroprotective effect of propofol has been reported. We aimed to identify whether propofol induced HSPs expression and protected BBB integrity. Mouse astrocytes and microglia cells were cultured and exposed to hypoxia and propofol. The expression of HSP27, HSP32, HSP70, and HSP90, and the translocation of heat shock factor 1 (HSF1) and...
Paper Details
Title
The effect of propofol on hypoxia-modulated expression of heat shock proteins: potential mechanism in modulating blood–brain barrier permeability
Published Date
Aug 24, 2019
Volume
462
Issue
1-2
Pages
85 - 96
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