Population pharmacokinetics of dolutegravir: influence of drug–drug interactions in a real-life setting

Dolutegravir is widely prescribed owing to its potent antiviral activity, high genetic barrier and good tolerability. The aim of this study was to characterize dolutegravir's pharmacokinetic profile and variability in a real-life setting and to identify individual factors and co-medications affecting dolutegravir disposition.A population pharmacokinetic model was developed using NONMEM®. Relevant demographic factors, clinical factors and...