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Should We Be Doing Cytoreductive Surgery with HIPEC for Signet Ring Cell Appendiceal Adenocarcinoma? A Study from the US HIPEC Collaborative.

Published on Aug 19, 2019in Journal of Gastrointestinal Surgery2.69
· DOI :10.1007/s11605-019-04336-4
Nick C. Levinsky3
Estimated H-index: 3
(University of Cincinnati Academic Health Center),
Mackenzie C. Morris1
Estimated H-index: 1
(University of Cincinnati Academic Health Center)
+ 25 AuthorsSameer H. Patel14
Estimated H-index: 14
(University of Cincinnati Academic Health Center)
Abstract
Background Appendiceal adenocarcinoma with signet ring cells (SCA) is associated with worse overall survival (OS), and it is unclear whether cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) should be pursued in this patient population. We assessed the prognostic implications of signet ring cells in patients with appendiceal adenocarcinoma and peritoneal carcinomatosis undergoing CRS-HIPEC.
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