Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice.
Abstract
Human and rodent brown adipose tissues (BAT) appear morphologically and molecularly different. Here we compare human BAT with both classical brown and brite/beige adipose tissues of ‘physiologically humanized’ mice: middle-aged mice living under conditions approaching human thermal and nutritional conditions, that is, prolonged exposure to thermoneutral temperature (approximately 30 °C) and to an energy-rich (high-fat, high-sugar) diet. We find...
Paper Details
Title
Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice.
Published Date
Aug 1, 2019
Journal
Volume
1
Issue
8
Pages
830 - 843
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